Fig. 7: The p38-MK2 signaling pathway drives the inflammatory gene expression in response to ischemia. | Cell Death & Disease

Fig. 7: The p38-MK2 signaling pathway drives the inflammatory gene expression in response to ischemia.

From: Involvement of p38 MAPK and MAPKAPK2 in promoting cell death and the inflammatory response to ischemic stress associated with necrotic glioblastoma

Fig. 7

A A diagram describing the steps for analyzing and comparing differentially expressed genes in ischemic LN229 cells and the GBM PNZ relative to control LN229 cells and the GBM CT area, respectively. B, C Differentially expressed genes when comparing cells under the ischemic condition treated by VX745 (B) or MK25 (C) to those treated by a DMSO control. D Venn diagram showing overlapping genes in between indicated conditions. E, F Ingenuity Pathway Analysis identified upstream regulators under each indicated culture condition. G LN229KRAS(G12D) or LN229PIK3CA(H1047R) cells cultured under a regular (control) or the ischemic condition, treated by indicated inhibitors or DMSO were subjected to q-RT-PCR for TNFα mRNA. Ordinary two-way ANOVA test. H A diagram illustrating the involvement of the p38-MK2 and UPR signaling pathways in mediating ischemic stress-induced inflammatory response and cell death.

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