Fig. 7: piR-26441 overexpression inhibits OC growth in vivo and in patient-derived organoids (PDOs). | Cell Death & Disease

Fig. 7: piR-26441 overexpression inhibits OC growth in vivo and in patient-derived organoids (PDOs).

From: piR-26441 inhibits mitochondrial oxidative phosphorylation and tumorigenesis in ovarian cancer through m6A modification by interacting with YTHDC1

Fig. 7

a–c Tumor volume of nude mice inoculated with ago-piR-26441 CAOV3 cells decreased. d The levels of YTHDC1 protein increased and the levels of TSFM protein decreased in subcutaneous xenografts of nude mice. e OC organoids became smaller in size after inoculation with ago-piR-26441. f The results of the R01 fluorescent probe assay showed the oxygen consumption rate decreased in the inoculated ago-piR-26441 PDOs. g The molecular mechanism of piR-26441. All independent experiment repeated three times. Values are presented as the mean ± SD. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001.

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