Fig. 7: Acetylation of ERRα facilitated the tumorigenesis of RCC. | Cell Death & Disease

Fig. 7: Acetylation of ERRα facilitated the tumorigenesis of RCC.

From: Hypoxia-triggered ERRα acetylation enhanced its oncogenic role and promoted progression of renal cell carcinoma by coordinating autophagosome-lysosome fusion

Fig. 7

A IF results showed that overexpression of WT ERRα but not 4KR could resuced the blockage effect of ERRα on autophagy flux in Caki-1 cells, column chart revealed the relative autolysosomes in different cells, ***p < 0.001, ns p > 0.05. B CCK8 assays evaluated the growth curves of OS-RC-2 cells overexpressed with Ctrl (Vector), WT, KR or WT treatment with CBP-30, ***p < 0.001. C Transwell assays tested the migration and invasion of OS-RC-2 cells from four groups indicated. D–F OS-RC-2 cells stably overexpressing the Ctrl (Vector), WT or KR were subcutaneously injected into mouse and one WT group were treated with CBP-30, the tumor volume were monitored every two days, the results were shown using with line chart (D), 21 days post injection, the mice were sacrificed and the tumors were removed, captured and weighed, the image and tumor weights were showed in E and F. Data were shown with means ± SD, n = 5 for each group, ***p < 0.001. G IHC assays revealed the expression of Ki67 in tumor tissues from four indicated groups. H Scatter diagram showed the IHC socres of Ki67 in four groups of mice. **p < 0.01, ***p < 0.001.

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