Table 1 The distribution of M1/M2 tumor-associated macrophage in wild-type or mutant EGFR and TP53 lung adenocarcinoma.

From: Tp53 determines the spatial dynamics of M1/M2 tumor-associated macrophages and M1-driven tumoricidal effects

 

EGFR

 

TP53

 

wt

mutant

p-value

wt

mutant

p-value

 

N (%)

24

93

 

33

84

 

M1

Islets

   

0.07

  

0.02*

 

Low

19 (79)

55 (59)

 

22 (67)

72 (86)

 
 

High

5 (21)

38 (41)

 

11 (33)

12 (14)

 

Stroma

   

0.42

  

0.38

 

Low

12 (50)

55 (59)

 

21 (64)

46 (55)

 
 

High

12 (50)

38 (41)

 

12 (36)

38 (45)

 

M2

Islets

   

0.11

  

0.03*

 

Low

20 (83)

80 (86)

 

24 (73)

76 (90)

 
 

High

4 (17)

13 (14)

 

9 (27)

8 (10)

 

Stroma

   

0.31

  

0.24

 

Low

15 (63)

68 (73)

 

26 (79)

57 (68)

 
 

High

9 (37)

25 (27)

 

7 (21)

27 (32)

 
  1. The cell count is calculated by the positive cell number divided the indicated tissue area (mm2). Low: 0–100; High: >100 cells per mm2.
  2. *Chi-square test, p < 0.05.
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