Fig. 11: Androgen promotes melanoma immune-escape by NK cells and invasiveness: graphical representation. | Cell Death & Disease

Fig. 11: Androgen promotes melanoma immune-escape by NK cells and invasiveness: graphical representation.

From: Role of the androgen receptor in melanoma aggressiveness

Fig. 11

Androgen stimulation of melanoma cells triggers the assembly of the AR/ADAM10/β1 integrin complex. Such complex enables ADAM10 to act as MICA sheddase, on one hand. The MICA shedding, hence, causes the effective masking from NKG2D recognition allowing the immune-escape. On the other, the complex mediates the androgen-induced invasiveness of melanoma cells through the activation of FAK and ERK.

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