Fig. 6: MAPK4 KO mice exhibit impaired TI humoral immune responses. | Cell Death & Disease

Fig. 6: MAPK4 KO mice exhibit impaired TI humoral immune responses.

From: MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway

Fig. 6

WT and MAPK4 KO mice were immunized with the T cell-independent antigen NP-Ficoll or the T cell-dependent antigen NP-KLH for 14 days, followed by flow cytometry analysis of B cell subpopulations. A, B Analysis of FO, T1 and T2 cell subpopulations (n = 4). C Proportions and absolute numbers of FO, T1 and T2 cells (n = 4). D, E Analysis of MZ cell subpopulations (n = 4). F, G Analysis of GC cell subpopulations (n = 4). H-I Analysis of MBC cell subpopulations (n = 4). J Proportions and absolute numbers of MZ cell (n = 4). K-L Analysis of PC cell subpopulations (n = 4). M Proportions and absolute numbers of GC cells (n = 4). N Proportions and absolute numbers of MBC cells (n = 4). O Proportions and absolute numbers of PC cells (n = 4). P Specific serum IgM and IgG1 levels were detected by ELISA in WT and MAPK4 KO mice immunized with NP-Ficoll (n = 4). Q Specific serum IgM and IgG1 levels were detected by ELISA in WT and MAPK4 KO mice immunized with NP-KLH (n = 4). *P < 0.05; **P < 0.01; ***P < 0.001.

Back to article page