Fig. 6: Working Model. | Cell Death & Disease

Fig. 6: Working Model.

From: Positive feedback loop involving AMPK and CLYBL acetylation links metabolic rewiring and inflammatory responses

Fig. 6

External stimuli activate TLR signal, which impedes SIRT2 to deacetylate CLYBL and promotes pro-inflammatory cytokines production in an AMPK-dependent manner. In turn, hyperacetylation of CLYBL mediates hypophosphorylation of AMPK, which further promotes the hypercaetylation of CLYBL. The activation of this feedback loop increases IL-6 and IL-1β release through TCA cycle rewiring, leading to cardiac remodeling.

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