Fig. 7: RAD51 is required for GBM resistant to TMZ treatment in vivo. | Cell Death & Disease

Fig. 7: RAD51 is required for GBM resistant to TMZ treatment in vivo.

From: Overexpression of miR-124 enhances the therapeutic benefit of TMZ treatment in the orthotopic GBM mice model by inhibition of DNA damage repair

Fig. 7

A HE staining showing representative images (present 3 samples per group) of gross tumors (location near the lateral ventricle) from two rescue treatment groups in mouse orthotopic model. Scale bar, 1 mm. B, C Statistic of tumor size or tumor occupancy rate from two rescue treatment groups in (C) (n = 5 per group). D–F Representative images (top) and quantification of γ-H2AX, Ki67 and TUNEL positive immunofluorescence area (bottom) in the two rescue treatment groups. Scale bar in low-power microscope 500 μm, in high-power microscope 150 μm. All experiments were repeated at least 3 times. Above data are presented as means ± SD. P values were calculated using unpaired Student’s t-test.

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