Fig. 6: Adipogenic and pro-fibrotic effects of IL-32 on cardiac mesenchymal stromal cells (C-MSC) of ACM or HC. | Cell Death & Disease

Fig. 6: Adipogenic and pro-fibrotic effects of IL-32 on cardiac mesenchymal stromal cells (C-MSC) of ACM or HC.

From: Analysis of effector/memory regulatory T cells from arrhythmogenic cardiomyopathy patients identified IL-32 as a novel player in ACM pathogenesis

Fig. 6

a, b Nile red staining showing lipid accumulation in C-MSC in basal conditions and after treatment with IL-32 20 ng/ml for 3 days (a), and its quantification (b) showed by sum nile red intensity per number of nuclei. c, d Immunohistochemistry showing collagen accumulation in C-MSC in basal conditions or after treatment with IL-32 20 ng/ml for 3 days (c) and its quantification (d) showed by sum 488 intensity per number of nuclei. Data are shown as mean ± SEM. ***p < 0.001, **p < 0.01, *p < 0.05 using two-way ANOVA test followed by Tukey’s multiple comparisons test. Scale bars: 50 µm.

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