Fig. 6: The lack of CrT induces mitochondriogenesis and specific atrophy programs. | Cell Death & Disease

Fig. 6: The lack of CrT induces mitochondriogenesis and specific atrophy programs.

From: Creatine transporter (SLC6A8) knockout mice exhibit reduced muscle performance, disrupted mitochondrial Ca2+ homeostasis, and severe muscle atrophy

Fig. 6

A Representative Western blot of WT and CrT−/y EDL muscles stained with the indicated antibodies. α-CoxIV was used as loading control. n = 3. B–D Quantification of the experiment performed as in (A). Data are presented as mean ± SEM. n = 4. For data analysis, parametric Student t-test (two-tailed, unpaired) was used. *p < 0.05. E Real-time RT-PCR analyses of WT and CrT−/y muscles with the indicated oligonucleotide primers. Data are presented as mean ± SEM. n = 5. For data analysis, parametric Student t-test (two-tailed, unpaired) was used. ***p < 0.001.

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