Fig. 4: TRIM21 decreases the protein stability of PRMT1 in CRC cells.
From: TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression
A, B The mutual interaction between TRIM21 and PRMT1 were detected by Co-IP. C, D Western blot analysis was used to detect PRMT1 protein expression in TRIM21 deficiency (C) or TRIM21 overexpression (D) cells. E, F qPCR analysis was used to detect PRMT1 mRNA expression in TRIM21 deficiency (E) or TRIM21 overexpression (F) cells. G Effect of TRIM21 on PRMT1 protein half-life in HCT-116 cells overexpressing TRIM21 and treated with CHX. Data are represented as mean ± SD of three independent experiments, and ns (no significance), **p < 0.01 (Student’s t-test).
