Fig. 7: TRIM21 affects the CRC progression in a PRMT11-dependent manner in vivo.
From: TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression
A, B Tumor tissue images (A), tumor volume statistical curves (B) of HCT116 tumor-bearing mice in indicated groups (n = 6 for each group). C IHC staining was performed on the subcutaneous tumor tissue to analyze the expression of TRIM21, PRMT1, and Ki-67. D Lung metastatic nodules were examined macroscopically after nude mice were sacrificed. The red arrows denote the metastatic nodules. E Bouin staining and HE staining of lung metastases after tail vein injection of BALB/C nude mice (Left panel). statistical analysis of lung nodule numbers (Right panel). Data were expressed as the mean ± SD (*P < 0.05, **P < 0.01, *** P < 0.001). F A proposed working model for this study. TRIM21-mediated PRMT1 K48-linked ubiquitination decreases PRMT1 expression, which suppresses the proliferation, tumorigenesis, migration, and metastasis of CRC cells.
