Fig. 3: PrP106–126-induced oxidative stress leads to mitochondrial dysfunction in N2a cells. | Cell Death & Disease

Fig. 3: PrP106–126-induced oxidative stress leads to mitochondrial dysfunction in N2a cells.

From: Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases

Fig. 3

A, B Detection of mtROS production in N2a cells treated with irisin and PrP106–126, analyzed using MitoSOX staining and flow cytometry. C–F Measurement of MDA content, GSH/GSSH ratio, and CAT and T-SOD activities in N2a cells. The data are presented as the means ± SDs (n = 6), *P < 0.05; **P < 0.01; ***P < 0.001.

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