Fig. 6: Irisin maintains mitochondrial function via UCP2. | Cell Death & Disease

Fig. 6: Irisin maintains mitochondrial function via UCP2.

From: Irisin regulates oxidative stress and mitochondrial dysfunction through the UCP2-AMPK pathway in prion diseases

Fig. 6

A, D The representative images of mitochondrial morphology and the quantification of mitochondrial length (scale bar = 10 µm). B Transmission electron microscopy was used to observe the mitochondrial ultrastructure of the cells (scale bar = 500 nm). C, E Measurement of mitochondrial membrane potential by JC-1 probes. F The mtDNA/nDNA ratio was assessed by real-time PCR. G Measurement of ATP levels. H–K The activity of the mitochondrial respiratory chain complexes (I–IV). The data are presented as the means ± SDs (n = 6), *P < 0.05; **P < 0.01; ***P < 0.001.

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