Fig. 5: CDCA7 promotes PC cell progression and gemcitabine resistance by targeting STAT3 to regulate glycolysis levels. | Cell Death & Disease

Fig. 5: CDCA7 promotes PC cell progression and gemcitabine resistance by targeting STAT3 to regulate glycolysis levels.

From: CDCA7 enhances STAT3 transcriptional activity to regulate aerobic glycolysis and promote pancreatic cancer progression and gemcitabine resistance

Fig. 5

PANC-1 and MIA PaCa-2 were transfected with or without plasmids to generate Vector, CDCA7 overexpression, and CDCA7 + sh-STAT3 groups. A CCK-8, (B) plate clone, (C) EDU assays (scale bar: 50 μm). D Wound healing (scale bar: 200 μm) and (E) Transwell assays. F–H Detection of extracellular glucose and lactate levels and intracellular ATP levels in PC cells. I CCK-8 assay was performed to detect the sensitivity of each group to gemcitabine. *P < 0.05, **P < 0.01, ***P < 0.001.

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