Fig. 2: Single-cell sequencing shows MTCH2 overexpression in the prostate cancer epithelium. | Cell Death & Disease

Fig. 2: Single-cell sequencing shows MTCH2 overexpression in the prostate cancer epithelium.

From: Identification of mitochondrial carrier homolog 2 as an important therapeutic target of castration-resistant prostate cancer

Fig. 2

Dimensionality reduction visualization showing cell annotations in the GEO single-cell dataset GSE181294 (A). A dimensionality reduction visualization depicting described sample groupings (B). The dot plot analysis indicates significantly elevated MTCH2 expression within the epithelial cell population (C). The expression density analysis confirmed higher MTCH2 expression in the epithelial cells of the prostate cancer (“PRAD”) group compared to the normal prostate tissue (“NORM”) group (D). Subsequent extraction and sub-clustering of epithelial cells highlighting MTCH2 distribution in tumor epithelium (E). Detailed visualization of MTCH2 distribution in the tumor epithelium (F). Correlation analysis of MTCH2 expression within the epithelial cells, identifying the top 100 related genes, and Gene Ontology (GO) (G) and HALLMARK (H) enrichment analyses showing associations of MTCH2 with biological process and signaling cascades.

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