Fig. 5: TRF2 expression positively correlates with breast cancer progression and metastasis. | Cell Death & Disease

Fig. 5: TRF2 expression positively correlates with breast cancer progression and metastasis.

From: TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer

Fig. 5

A Representative images of immunohistochemistry evaluation of TRF2 expression in Normal breast tissue, Fibroadenoma (benign lesion), and Ductal carcinoma (malign tumor). Scale bars, 30 μm. B Quantification of TRF2 expression (Immunoreactive score) in Normal breast tissue (N = 41), benign lesions (N = 50), and malign tumors (N = 55) surgically treated in IRCCS-Regina Elena National Cancer Institute. Statistical significance was calculated by one-way ANOVA (****P < 0.0001). C Representative images of immunohistochemistry evaluation of TRF2 expression in primary TNBC and their matched metastatic lesions (local recurrence and different distant organs). Scale bars, 30 μm. D Quantification of TRF2 expression (Immunoreactive score) in primary TNBC and their autologue metastatic lesions from patients surgically treated in IRCCS-Regina Elena National Cancer Institute (N = 30). Statistical significance was calculated by Wilcoxon matched-pairs rank test (****P < 0.0001). Overall survival (OS) evaluated by Kaplan-Meier curves on all stages (E) or stages I-II-III (F) BC patients from the TCGA dataset. Patients were stratified on the basis of TRF2 mRNA expression. Statistical significance was calculated by logrank test (*P < 0.05).

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