Fig. 6: The association of TRF2 with the inner nuclear membrane complex occurs through a direct interaction with Emerin. | Cell Death & Disease

Fig. 6: The association of TRF2 with the inner nuclear membrane complex occurs through a direct interaction with Emerin.

From: TRF2 interaction with nuclear envelope is required for cell polarization and metastasis in triple negative breast cancer

Fig. 6

This allows proper establishment of cell polarity and directional migration of cancer cells from primary tumor to distant site of the body giving rise to spontaneous metastasis. Knockdown of TRF2 increases nuclear circularity, reduces cell stiffness, impairs cell polarity and directional cell migration, finally leading to reduced metastasis formation. TRF2 expression results higher in the metastatic lesion as compared to matched primary tumor.

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