Fig. 9: Schematic diagram of the PSMD14-CARM1-FERMT1 axis in HCC. | Cell Death & Disease

Fig. 9: Schematic diagram of the PSMD14-CARM1-FERMT1 axis in HCC.

From: PSMD14-mediated deubiquitination of CARM1 facilitates the proliferation and metastasis of hepatocellular carcinoma by inducing the transcriptional activation of FERMT1

Fig. 9

PSMD14-mediated deubiquitination upregulates CARM1 expression, which in turn transcriptionally activates its downstream target FERMT1 through histone H3R17me2. This PSMD14-CARM1-FERMT1 signaling axis significantly promotes HCC growth and metastasis. Pharmacological inhibition of CARM1 using SGC2085 effectively suppresses the malignant phenotypes of HCC cells, suggesting a potential therapeutic strategy for HCC treatment.

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