Fig. 2: YTHDC1 impacts BNL CL2 cell viability and apoptotic induction following radiation-induced injury. | Cell Death & Disease

Fig. 2: YTHDC1 impacts BNL CL2 cell viability and apoptotic induction following radiation-induced injury.

From: The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3 following its METTL3-mediated m6A methylation: a novel mechanism early during radiation-induced liver injury

Fig. 2

A Western blotting revealed the downregulation of YTHDC1 in BNL CL2 cells on day 2 post irradiation (**P < 0.01). B Flow cytometry was used to examine the impact of YTHDC1 on BNL CL2 cell apoptosis on day 2 post irradiation (**P < 0.01). C. A CCK-8 assay was used to examine the impact of YTHDC1 on BNL CL2 cell viability with or without irradiation (**P < 0.01). D. The methylation level of MEG3 in BNL CL2 cells a at 2 d after 6 Gy radiation was detected by MeRIP assay (**P < 0.01). A, B, D, n = 3; C, n = 5. A, B were followed by one-way ANOVA. C, D were performed by two-tailed unpaired T-test.

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