Fig. 2: Structure of EN460 derivatives. | Cell Death & Disease

Fig. 2: Structure of EN460 derivatives.

From: Small molecule-mediated inhibition of the oxidoreductase ERO1A restrains aggressive breast cancer by impairing VEGF and PD-L1 in the tumor microenvironment

Fig. 2

Chemical structures of EN460. Each modified group in EN460 is boxed with a different color. The chemical substitutions of EN460 analogs (I1–14) are indicated and color- boxed. The phenyl of EN460 is depicted in red; analogs I1, I2, I3, I4 and I6 encompass the substitution of this group and are boxed in red. The phenyl-furan moiety of EN460 is depicted in blue, and the designated analogs with substitution of this group (I8-I15) are boxed in blue. The α, β unsaturated double bond is in green, and the analog with substitution of this group (I15) is also boxed in green. The side chain trifluoromethyl of pyrazolone is in purple and the analogs with substitution of this group (I14 and I10) are boxed in purple. Below, boxed in black, are commercially available analogs of EN460 putatively matching its activity profile while presenting a different chemical structure (I17–I23) and I16, a conjugate of N-acetylcysteine (NAC) and S-acetyl-β-mercaptoethylamine (SMEA).

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