Fig. 1: miR-379-5p is downregulated in ovarian CSCs. | Cell Death & Disease

Fig. 1: miR-379-5p is downregulated in ovarian CSCs.

From: MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis

Fig. 1

A The GEO dataset GSE107155 was reanalyzed to identify a list of differentially expressed microRNAs in ovarian cancer cell line SKOV3 grown in adherent and spheroid cultures. B qPCR analysis showed decreased miR-379-5p expression in spheroids derived from ovarian cancer cell lines and HGSOC patients. C Representative H&E of normal tissue and tumor tissue derived from ovarian cancer patients. D Pan-cancer expression profiling of miR-379-5p in normal vs tumor samples using CancerMIRNome (Wilcoxon rank-sum test, ***: P < 0.001; **: P < 0.01; *: P < 0.05; ns: P > 0.05). E Colony formation assay was conducted on control and miR-379-5p-overexpressing OC cells. F Representative images show spheroid formation ability in control and miR-379-5p-overexpressing ovarian CSCs (n = 3, Bar, SD; Significance levels denoted as ns > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001).

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