Fig. 3: miR-379-5p enhances the sensitivity of CSCs to cisplatin while decreasing the expression of genes associated with stemness. | Cell Death & Disease

Fig. 3: miR-379-5p enhances the sensitivity of CSCs to cisplatin while decreasing the expression of genes associated with stemness.

From: MicroRNA-379-5p attenuates cancer stem cells and reduces cisplatin resistance in ovarian cancer by regulating RAD18/Polη axis

Fig. 3

A Propidium iodide (PI) live-dead assay on OVCAR3 spheroid cells and OV2008 CD44 + CD117+ cells exhibit higher cytotoxicity in cells overexpressing miR-379-5p upon treatment with cisplatin. The accompanying chart illustrates the percentage of cell death. B In SKOV3 spheroids, OV2008 CD44 + CD117+ cells, and OVCAR3 spheroids, the overexpression of miR-379-5p significantly diminishes the expression of stem cell marker genes such as oct4, sox2, and nanog (n = 3, Bar, SD; Significance levels are denoted as *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001).

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