Fig. 6: circABCC4 regulates oxaliplatin resistance induced by CAFs in mice. | Cell Death & Disease

Fig. 6: circABCC4 regulates oxaliplatin resistance induced by CAFs in mice.

From: Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation

Fig. 6

A Once 12 days after implantation, xenograft orthotopic model receiving oxaliplatin (5 mg/kg) once every 3 days. B, C Analysis of luminescence intensity in orthotopic xenograft model. The relative luminescence intensity = (Xday27-Xday12)/average (shNegday27-shNegday12). D Analysis of orthotopic tumor volume. The results are presented as the mean ± SD. N = 5/per group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. ns no significance. E Representative IVIS images and pancreatic tumors in orthotopic xenograft model. F Representative images of immunofluorescence analysis of IL-8, α-SMA, γH2AX and TUNEL assays of orthotopic model. G, H Quantification of the presence of IL-8+ (G), the number of γh2ax-positive foci (H) and TUNEL-positive cells (I) in each group.

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