Table 1 Univariate and multivariate analyses of factors associated with overall survival and progression-free survival in patients with nasopharyngeal carcinoma.

From: Tumor vascular endothelial cells promote immune escape by upregulating PD-L1 expression via crosstalk between NF-κB and STAT3 signaling pathways in nasopharyngeal carcinoma

Variable

Overall survival

Progression-free survival

Univariate cox

Multivariate cox

Univariate cox

Multivariate cox

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

Age

 <50

 

1

   

1

  

 > =50

0.534

1.188 (0.690–2.046)

  

0.999

1.000 (0.628–1.591)

  

Gender

 Female

 

1

   

1

  

 Male

0.751

0.908 (0.502–1.645)

  

0.464

0.830 (0.505–1.365)

  

PD-L1 expression in Tumor vascular endothelial cells

 Negative

 

1

 

1

 

1

 

1

 Positive

<0.001

8.300 (4.539–15.177)

<0.001

8.700 (4.747–15.943)

<0.001

4.130 (2.579-6.612)

<0.001

4.216 (2.624-6.776)

CD31

 Negative

 

1

   

1

  

 Positive

0.905

1.064 (0.384–2.951)

  

0.827

1.107 (0.446–2.743)

  

T classification

 I-II

 

1

   

1

  

 III-IV

0.214

1.794 (0.713–4.514)

  

0.217

1.634 (0.750–3.558)

  

N classification

 0-1

 

1

 

1

 

1

 

1

 2-3

0.006

2.188 (1.253–3.818)

0.040

1.799 (1.026–3.154)

0.001

2.163 (1.348–3.471)

0.014

1.824 (1.127–2.951)

EBV-DNA

 <2000

 

1

 

1

 

1

 

1

 > =2000

0.030

1.887 (1.062–3.353)

0.010

2.144 (1.198–3.836)

0.059

1.576 (0.983–2.527)

0.049

1.622 (1.000–2.631)

Treatment

 CCRT

 

1

   

1

  

 CCRT + IC/AC

0.399

1.307 (0.701–2.435)

  

0.582

1.159 (0.684–1.964)

  

 Radiotherapy

0.454

1.443 (0.553–3.767)

  

0.136

1.781 (0.833–3.807)

  

Targeted therapy

 NO

 

1

   

1

  

 YES

0.698

0.898 (0.523–1.544)

  

0.731

0.922 (0.582–1.463)

  
  1. CCRT, concurrent chemoradiotherapy, IC, induction chemotherapy, AC, adjuvant chemotherapy. Bold values indicate significance at P < 0.05.
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