Fig. 6: LONP1 overexpression induces tumorigenesis and metastasis in spontaneous prostate adenocarcinoma model.

A Macroscopic images of the prostate tissues were dissected from WT, Lonp1^KI, Pten^−/− and Pten^−/−; Lonp1^KI mice at 40 weeks of age. B The weight of prostates excised from the mice at 40 weeks of age was measured. C HE staining was performed on prostates excised from the mice at 40 weeks of age. Scale bars: 100 and 20 μm. D, E Immunohistochemistry staining of α-SMA (D) and P63 (E) was performed on prostates at 40 weeks. Scale bars: 200 and 50 μm. F, G HE and AR staining were performed on para-aortic lymph nodes (F) and lungs (G) excised from Pten^−/− and Pten^−/−; Lonp1^KI mice. Scale bars: 100 and 50 μm. Data are represented as mean ± SD. *P < 0.05; **P < 0.01.