Fig. 1: RAB33A enhances metastatic potential in cervical cancer.

a Immunohistochemical staining for RAB33A in cervical carcinoma specimens delineating cases without metastasis or recurrence from those with distant metastasis. b Overall survival (OS) and distant metastasis-free survival (DMFS) curves based on RAB33A protein levels in 50 paraffin-embedded cervical carcinoma tissues; patients with elevated RAB33A expression had reduced overall survival (P = 0.0136) and an increased risk of distant metastasis (P = 0.0216). c Migration and invasion of HeLa or SiHa cells overexpressing RAB33A. d Migration and invasion of HeLa or SiHa cells with or without RAB33A knockdown. e, f In vivo model of cervical cancer lymph node metastasis established using the indicated stable cell lines; the model was established in 9 biologically independent mice. Dissected popliteal and inguinal LNs (e) and their volumes (f) from mice with tumors derived from wild-type or RAB33A-knockout HeLa cells. The data are presented as the mean ± SD. P values are shown; two-tailed Student’s t-test. Vector vector-only control. WT wild type.