Fig. 6: ONECUT3 facilitates the deacetylation of HIF-1α and enhances its transcriptional activity through HDAC6. | Cell Death & Disease

Fig. 6: ONECUT3 facilitates the deacetylation of HIF-1α and enhances its transcriptional activity through HDAC6.

From: Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer

Fig. 6

A Western Blot showed HIF-1α acetylation level by detecting pan-acetylation antibody after knockdown of ONECUT3 or HDAC6 in HT29 cells. B Western blot analysis revealed the acetylation level of HIF-1α following the overexpression of ONECUT3 or the HDAC6 inhibitor (ACY241) in SW620 cells. C HIF-1 alpha Transcription Factor Assay kit showed the transcriptional activity of HIF-1α after overexpression of ONECUT3 or/and inhibition of HDAC6 in SW620 cells. *p < 0.05, **p < 0.01, ***p < 0.001. ns: no significance.

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