Fig. 8: Schematic representation of ONECUT3-HDAC6-HIF-1α axis that regulates proliferation in CRC.

ONECUT3 regulates HIF-1α deacetylation through HDAC6, enhancing HIF-1α transcriptional activity, which further promotes glycolysis in CRC cells and ultimately contributes to tumor progression. The original figure was created with BioRender.com.