Table 3 Splicing variants associated with tumor progression in EC.
From: The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer
Gene | Splice variant | Effect on tumor progression | Splicing regulator | Reference |
|---|---|---|---|---|
NF-Y | NF-YAl NF-YAs | In benign tissues. In EC tissues (especially high-grade) and is associated with tumor invasion ability. | Unknown | [175] |
FGFR2 | FGFR2b FGFR2c | In epithelial cells and is associated with better prognostic factors. In stromal cells and is associated with the aggressive characteristics of tumors. | ESERP1 ESERP2 | |
CYP24A1 | CYP24A1-SV | Promote the proliferation and survival of tumor cells, regulate tumor angiogenesis and influence the infiltration and activity of immune cells. | Calcitriol Progestogens | [178] |
p53 | Δ40p53 | Form aggregates in the cytoplasm and affect the tumor suppressive function of p53 | Unknown | [179] |
ER | ERαD7 ERβ5 | Negatively correlated with tumor grade and stage and positively correlated with disease-specific survival. Increase the sensitivity of ERα(+) EC cells to estrogen. | hnRNPG hTra2-β1 Unknown | |
DLX4 | BP1 | Promote tumor proliferation and migration. | Unknown | [182] |
GHRH | GHRH-SV1 | Promote cell proliferation and tumor growth. | Unknown | [183] |
Survivin | Survivin-ΔEx3 Survivin-2B | Promote the extrinsic apoptotic pathway. Promote the intrinsic apoptotic pathway. | Unknown | [184] |
TSNAX and DISCI | TSNAX-DISC1 | Promote G1-S phase cell cycle progression and cell proliferation. | CTCF lincRNA-NR_034037 | [185] |
Numb | Numb-L | Promote tumor growth. | miR-335 RBM10 | [186] |
TFRC | TFRC-S | Resistance to ferroptosis. | circRAPGEF5 RBFOX2 | [172] |
RCC1 | RCC1-T2 and RCC1-T3 | Promote tumor proliferation and migration. | SNORA73B | [187] |
FOXM1 | FOXM1b and FOXM1c | Promote cell proliferation, migration and invasion, and inhibit apoptosis. | SNORD14E | [173] |
ANKHD1 | ANKHD1-BP3 | Promote tumor metastasis. | HSPB1 | [170] |
