Fig. 8: MiR-769-5p is highly expressed in 5-FU-resistant CRC patients. | Cell Death & Disease

Fig. 8: MiR-769-5p is highly expressed in 5-FU-resistant CRC patients.

From: MiR-769-5p of macrophage exosomes induced by GRP78 promotes stemness and chemoresistance in colorectal cancer

Fig. 8

A The expression of miR-769-5p in tissues of 5-FU-sensitive (n = 20) and 5-FU-resistant (n = 20) CRC patients was examined by qRT-PCR. U6 was used as an internal control. B Statistical graph of miR-769-5p expression in CRC tissues in (A). C The expression of MAPK1 in tissues of 5-FU-sensitive (n = 20) and 5-FU-resistant (n = 20) CRC patients was examined by qRT-PCR. Actin was used as an internal control. D Statistical graph of MAPK1 expression in CRC tissues in (C). E The correlation between miR-769-5p and MAPK1 in CRC tissues was calculated by Spearman’s rank correlation method. F Research mechanism diagram by Figdraw. GRP78-induced macrophage-derived exosomes into CRC cells, which contain miR-769-5p targeting MAPK1, inhibited the expression of cell cycle-associated proteins by down-regulating MAPK1 and promoted the expression of stemness markers, leading to CRC resistance.

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