Fig. 8: Blocking TLR9 pathway enhances the therapeutic effect of sorafenib in HCC. | Cell Death & Disease

Fig. 8: Blocking TLR9 pathway enhances the therapeutic effect of sorafenib in HCC.

From: Circulating mitochondrial DNA promotes M2 polarization of tumor associated macrophages and HCC resistance to sorafenib

Fig. 8

A Schematic description of sorafenib and E6446 treatment in the DEN-induced HCC model (n = 4). B Representative micrographs of DEN-induced HCC treated as indicated (n = 4). C Body weight and the ratio of mouse liver tumors to liver area were detected in individuals of B (n = 4). D Flow cytometry analysis the macrophage infiltration in the DEN-induced HCC tissues treated as indicated (n = 4). E Representative immunohistochemical image of cleaved caspase-3 and Ki-67 in the DEN-induced HCC tissues treated as indicated, Scale bar: 100 μm.

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