Fig. 8: K383 acetylation of ACSL4 promotes the malignant progression of NPC. | Cell Death & Disease

Fig. 8: K383 acetylation of ACSL4 promotes the malignant progression of NPC.

From: HAT1/HDAC2 mediated ACSL4 acetylation confers radiosensitivity by inducing ferroptosis in nasopharyngeal carcinoma

Fig. 8

Subcutaneous injection of 2 × 106 SUNE1-NC or SUNE1-shHAT1 cells into nude mice to construct a xenograft model (n = 6). A Tumor size, B tumor volume and C tumor weight was measured. D IHC was used to detect the expression of HAT1, ACSL4, and Ki67 in tumor tissues. SUNE1-shACSL4-vec, SUNE1-shACSL4-WT, SUNE1-shACSL4-K383R, SUNE1-shACSL4-K383Q cells and HONE1-vec, HONE1-WT, HONE1-K383R, HONE1-K383Q cells were used. E Western blot was used to detect the protein expression of ACSL4, F CCK8 and G colony formation assay was used to detect the cell proliferation. H Scratch assay and I Transwell assay were used to detect the cell migration and invasion. Blank plasmid (vec), negative control (NC). The error line is expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001.

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