Fig. 7: J2H-1702 reduces fibrosis in a radiation-induced pulmonary fibrosis mouse model. | Cell Death & Disease

Fig. 7: J2H-1702 reduces fibrosis in a radiation-induced pulmonary fibrosis mouse model.

From: Inhibition of 11β-hydroxysteroid dehydrogenase 1 alleviates pulmonary fibrosis through inhibition of endothelial-to-mesenchymal transition and M2 macrophage polarization by upregulating heme oxygenase-1

Fig. 7

Male 7-to-8-week-old C57BL/6 mice were irradiated with 90 Gy using a 4 mm diameter field. A The radiation-induced white ring boundary in the lungs exhibits morphological changes according to drug administration. B Micro-CT images were acquired after drug administration. C H&E and Masson’s trichrome staining were performed in mice tissues. The fibrosis grade was evaluated according to the Ashcroft score, and collagen deposition was evaluated. (n = 4 animals per group). Error bars indicate the standard deviation (S.D); One-way ANOVA for multiple comparison. N.S, not significant. *P < 0.05, ***P < 0.001, and ****P < 0.0001.

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