Fig. 8: J2H-1702 controls EndMT and M2 macrophage polarization by elevating heme oxygenase-1. | Cell Death & Disease

Fig. 8: J2H-1702 controls EndMT and M2 macrophage polarization by elevating heme oxygenase-1.

From: Inhibition of 11β-hydroxysteroid dehydrogenase 1 alleviates pulmonary fibrosis through inhibition of endothelial-to-mesenchymal transition and M2 macrophage polarization by upregulating heme oxygenase-1

Fig. 8

J2H-1702 controls EndMT and M2 macrophage polarization by elevating heme oxygenase-1 (HO-1). HO-1 regulates reactive oxygen species-induced DNA damage in endothelial cells and also regulates IL-1β and arginase 1 in macrophages.

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