Fig. 5: Downregulation of TPM2 enhances tumor progression by acting on p38-MAPK pathway to promote ELANE expression in neutrophils. | Cell Death & Disease

Fig. 5: Downregulation of TPM2 enhances tumor progression by acting on p38-MAPK pathway to promote ELANE expression in neutrophils.

From: Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase

Fig. 5

A The expression of TPM2 in LUAD and para-cancerous normal tissues was detected. B Overall survival of patients with LUAD by TPM2 expression analyzed using Kaplan–Meier plot. C HE was used to detect TANs infiltration density in LUAD tissues. IHC was used to detect the expression level of TPM2 and TANs infiltration density in LUAD tissues. D The expression of TPM2 and the infiltration density of TANs in LUAD patients with or without lymph node metastasis and tumor recurrence were compared. E A-Neu were treated with different concentrations of exogenous TPM2 recombinant protein to detect ELANE, p38/MAPK, and p-p38/ MAPK protein levels. F, G TPM2-overexpressed A549 and TPM2-knockdown HCC827 and/or p38/ MAPK inhibitor SB202190 were co-cultured with A-Neu to detect ELANE expression levels. H, I TPM2-overexpressed A549 and TPM2-knockdown HCC827 were treated with or without ELANE inhibitors to detect Hippo pathway, Cycle, apoptosis, and EMT-maker protein expression levels.

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