Fig. 7: Lower TPM2 expression enhances tumor growth by activating neutrophils ELANE to promote neutrophil recruitment to tumor microenvironment in vivo. | Cell Death & Disease

Fig. 7: Lower TPM2 expression enhances tumor growth by activating neutrophils ELANE to promote neutrophil recruitment to tumor microenvironment in vivo.

From: Downregulation of tropomyosin 2 promotes the progression of lung adenocarcinoma by regulating neutrophil infiltration through neutrophil elastase

Fig. 7

A The bioluminescence imaging (BLI) in PLVX, Alvelestat, TPM2, and TPM2+Alvelestat treatment groups (n = 5). B Quantitation of total body bioluminescence intensity (n = 5). C Kaplan–Meier survival curves (n = 5). P values are determined by the Log-rank (Mantel–Cox) test. D, E HE and IHC were used to detect ELANE expression and neutrophil infiltration density in C57BL/6 mouse tumor tissues. F The apoptosis level of the C57BL/6 mouse tumor was detected. G, H IL-1β and IL-8 mRNA and protein levels in peripheral blood neutrophils of C57BL/6 mice were detected. p values were obtained by repeated measures two-tailed unpaired t-test; ****p < 0.0001; *p < 0.05; ns not significant.

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