Fig. 1: Sc-RNAseq analysis of B-ALL patients. | Cell Death & Disease

Fig. 1: Sc-RNAseq analysis of B-ALL patients.

From: UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia

Fig. 1

A Immunophenotyping of single-cell transcriptomes from patients with different disease states of B-ALL and HD. B UMAP diagram illustrates the distribution of clusters 2, 5, and 16 across different groups. C The Venn diagram revealed six significantly common DEGs. D The mRNA expression levels of UHRF1 in B-ALL Patients across varied disease states. E Paired analysis of mRNA expression levels of UHRF1 in mononuclear cells at relapse state vs. ND/CR state (left); Comparative analysis of mRNA expression levels of UHRF1 in CD19+ B cells (right). F Survival analysis of UHRF1 in B-ALL Patients within our center and the TARGET dataset. proB: B progenitor cells, RR: Relapsed/Refractory group, ND: Newly Diagnosed group, CR: Complete Remission group, HD: Healthy Donor group. #Mononuclear cells: including bone marrow mononuclear cells (BMMNCs) and peripheral blood mononuclear cells (PBMCs).

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