Fig. 7: UM164 inhibits leukemia cell progression in vivo. | Cell Death & Disease

Fig. 7: UM164 inhibits leukemia cell progression in vivo.

From: UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia

Fig. 7

A The process diagram for Nalm6-luc cells xenograft model construction and UM164 intervention therapy. B The survival of mice treated with the vehicle or UM164. C Bioluminescence imaging technology to evaluate the anti-leukemia effect of UM164 treatment. D The flow cytometry analysis of human CD45+CD19+ ratio in bone marrow, spleen, and peripheral blood cells isolated from the vehicle- or UM164-treated mice transplanted with Nalm6-luc cells (n = 5). E and F The HE stains analysis and immunohistochemical analysis of CD45 in spleen and BM cells isolated from the vehicle- or UM164-treated mice were performed 3 weeks after transplantation. The magnification of the images is ×200 for the full blots. N6-luc Nalm6-Luciferase.

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