Fig. 1: XIAP promotes bladder cancer metastasis.
From: XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
UMUC3/T24T with XIAP knockout (A), XIAP knockdown (B) and XIAP overexpression (C). Transwell assay was used to detect the effect of XIAP knockout on the migration and invasion ability of UMUC3 (D) and T24T (F) in vitro. The statistical results of migration and invasion ability of UMUC3 (E) and T24T (G). H T24T (WT-XIAP) and T24T (KO-XIAP) cells was injected into nude mice through the tail vein. The formation of lung metastases was observed 12 weeks later. I Paraffin embedding of lung tissue for HE staining analysis. J The number of lung metastases were counted. Data are represented as mean ± SD and *p < 0.05 between groups.
