Fig. 2: XIAP downregulated the expression of tumor suppressor YTHDC1.
From: XIAP promotes metastasis of bladder cancer cells by ubiquitylating YTHDC1
A The downstream targets of XIAP were analyzed by IP mass spectrometry and iTRAQ proteomics. B The TCGA database was used to analyze the differential expression of YTHDC1 in clinical bladder cancer samples. C Overall survival of YTHDC1 high expression group and low expression group. D, E IHC was used to analyze the differential expression of YTHDC1 protein in clinical bladder cancer samples. F, G The correlation of XIAP with YTHDC1 protein levels were analyzed. Data were analyzed using Pearson correlation. Western Blot was used to detect the protein expression levels of YTHDC1 after XIAP knockout (H), knockdown (I) or overexpression (J) in UMUC3/T24T cells.
