Fig. 8: Independent or combined regulation of TRMT10A and tRF-22 expression effectively inhibits VM formation and tumor growth in orthotopic xenografts in nude mice. | Cell Death & Disease

Fig. 8: Independent or combined regulation of TRMT10A and tRF-22 expression effectively inhibits VM formation and tumor growth in orthotopic xenografts in nude mice.

From: TRMT10A regulates tRNA-ArgCCT m1G9 modification to generate tRNA-derived fragments influencing vasculogenic mimicry formation in glioblastoma

Fig. 8

Immunohistochemical staining for TRMT10A, MXD1, and HIF-1α (A), as well as FISH staining for tRF-22 (B), in glioma samples. Data are presented as mean ± SD (n = 5). *P < 0.05, **P < 0.01 compared to the OE-NC + sh-NC group; ##P < 0.01 compared to the OE-TRMT10A group; &P < 0.05, &&P < 0.01 compared to the sh-tRF-22 group. Scale bar for IHC staining = 200 μm, Scale bar for FISH staining = 100 μm. C Schematic diagram of the TRMT10A/tRF-22/MXD1 pathway regulating VM formation in GBM.

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