Fig. 1: CXCL13 is increased in mice after PHx and in patients with liver resection.
From: CXCL13 suppresses liver regeneration through the negative regulation of HGF signaling
A, B Evaluation of cytokine levels in the serum of mice at 6 h after 2/3 PHx using a cytokine array. Representative images of membrane and the relative signal intensity of indicated cytokines were shown. C CXCL13 mRNA expression in liver tissues before and after PHx (n = 6). Statistical significance was made with the Mann–Whitney U test. D Western blot analysis of CXCL13 expression in liver tissues before and after 2/3 PHx, and the band intensity was quantified by densitometry (n = 6). Statistical significance was made with the Student’s t test. E Representative immunofluorescence images of CXCL13 (green) and DAPI (blue) in mouse livers before and after 2/3 PHx. F ELISA analysis of serum CXCL13 levels in patients pre- and post-LR (n = 34). Statistical significance was made with Student’s t test. G The correlations between the serum ALT, AST and CXCL13 levels in patients who underwent liver resection were evaluated by Spearman correlation analysis. Correlations were calculated by the Spearman correlation coefficient (n = 34).
