Fig. 4: PGM2L1 is a downstream regulatory target of CSF3/CSF3R signaling. | Cell Death & Disease

Fig. 4: PGM2L1 is a downstream regulatory target of CSF3/CSF3R signaling.

From: Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming

Fig. 4

A Heat map of top 80 metabolic pathways-related DEGs in both CSF3 and CAF-CM groups. B The expression level of top differential genes by qRT-PCR (n = 3). C The protein level of PGM2L1 was upregulated by CSF3 and CAF-CM. The expression level of PGM2L1 was decreased by silencing CSF3R in mRNA level (D, n = 3) and protein level (E). Colorimetry assays to measure glycolysis of MDA-MB-231 and MDA-MB-468 cells under hypoxia, including glucose (F), lactic acid (G), ATP (H), and G-6-P (I) (n = 3). The data are presented as the mean ± SD. ns, no significance; *P < 0.05, **P < 0.01, ***P <0.001.

Back to article page