Fig. 6: Down-regulation CSF3R inhibits PGM2L1-mediated TNBC progression and glycolytic reprogramming. | Cell Death & Disease

Fig. 6: Down-regulation CSF3R inhibits PGM2L1-mediated TNBC progression and glycolytic reprogramming.

From: Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming

Fig. 6

Following CSF3R-siRNA and PGM2L1-ove plasmid transfection, TNBC cells were tested by glycolysis level, including glucose (A), lactic acid (B), ATP (C), and G-6-P (D) (n = 3). MTT(E, n = 4) and EdU (F, n = 3) assays were performed to assessed cellular proliferation ability. Scale bars, 100 μm. G Transwell assay was employed to appraise cells migration and invasion abilities (n = 3). Scale bars, 200 μm. The data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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