Fig. 7: Inhibition of PRKCSH enhances the sensitivity of colorectal cancer xenograft tumor to radiation in vivo.
From: PRKCSH enhances colorectal cancer radioresistance via IRE1α/XBP1s-mediated DNA repair
A Overview of the animal experiment design. B Photographs of xenograft tumors taken 28 days after 15 Gy radiotherapy in the pelvic cavity. C Tumor volume growth in PRKCSH-NC and PRKCSH-KD groups, with and without ionizing radiation (IR). D Tumor weight measured at the time of sacrifice. E Western blot analysis of the IRE1α pathway and DNA damage repair signaling, showing data from a representative animal in each group. F–J Immunohistochemical images showing γH2AX, TUNEL, and Ki67 staining in tumor sections, based on representative tumors from each group. G–K Quantitative analysis of mean density for γH2AX, TUNEL, and Ki67 in tumors. Data are from three independent experiments. Error bars represent SD. ns indicates no significant difference; *P < 0.05, **P < 0.01, ***P < 0.001.
