Fig. 3: Evaluation of Mitochondrial functionality through Seahorse Mito Stress Test. | Cell Death & Disease

Fig. 3: Evaluation of Mitochondrial functionality through Seahorse Mito Stress Test.

From: Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family

Fig. 3

OCR (A) and ECAR (B) profiles, expressed as pmol O2/min/µg proteins and mpH/min/µg proteins in control and TDP-43G376D mutant fibroblasts, following the sequential addition of1 µM oligomycin A, 2 µM FCCP and 1 µM rotenone/antimycin A. Analysis of key mitochondrial parameters (C) and coupling efficiency (D). Bars indicate the mean ± SEM of at least three independent experiments replicates. Statistical significance: *p < 0.05, **p < 0.01, *** p < 0.001 (One-way ANOVA test with Tukey’s correction).

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