Fig. 4: Analysis of oxidative stress. | Cell Death & Disease

Fig. 4: Analysis of oxidative stress.

From: Mitochondrial and energy metabolism dysfunctions are hallmarks of TDP-43G376D fibroblasts from members of an Amyotrophic Lateral Sclerosis family

Fig. 4

Total intracellular glutathione (A), total ROS (B), and cytosolic superoxide anion (O2-) content (C). Data represented the mean of at least three independent experiments and results are shown as the mean ± SEM. Statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 (One-way ANOVA test with Tukey’s correction). Representative Western blot (D) and the expression level of SOD1 (16 kDa) (E) and SOD2 (22 kDa) (F) and their expression levels in unrelated controls and TARDBP-ALS family fibroblasts compared to loading control (Vinculin 121 kDa).

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