Table 2 Biochemical function of PRC2 subunits.
From: Unravelling the impact of the chromobox proteins in human cancers
PRC2 | Subunit | Motif/domains | function | Ref |
|---|---|---|---|---|
Core | EZH1 EZH2 | N-terminal WD repeat binding domain SANT domain CXC domain C-terminal SET domain | Histone methyltransferase (H3K27me3) | [164] |
Core | EED | WD-40 repeats | Allosteric activation of EZH1/EZH2 | [165] |
Core | SUZ12 | C-terminal VEFS Box | Stability of core | [22] |
Core | RBBP4 RBBP7 | WD40 repeats | Binding to nucleosome | [166] |
PRC2.1 | PCL1 or PHF1 PCL2 or MTF2 PCL3 or PHF19 | N-terminal TUDOR domain PHD-type zinc finger C-terminal Polycomb like MTF2 factor 2 domain | Binding to H3K36me3 recruiting PRC2.1 | [167] |
PRC2.1 | EPOP | BC box | Connecting Elonging BC to PRC2 core | [168] |
PRC2.1 | PALI1 | Helix-turn-helix DNA binding domain | Facilitating chromatin binding and enhancing PRC2 activity | [169] |
PRC2.2 | JARID2 | ARID DNA Binding domain Jmj domain Zinc finger | Enhancement of PRC2 methyltransferase activity and recruitment of the complex to H2AK119ub1 | [170] |
PRC2.2 | AEBP2 | Zinc finger | Enhancement of PRC2 methyltransferase activity and recruitment of the complex to H2AK119ub1 | [27] |
CATACOMB-containing PRC2 | CATACOMB | Serine rich domain | Allosteric inhibition of PRC2 | [171] |
