Fig. 1: Untargeted metabolomic analysis of the plasma from Scl/tTA-BCR::ABL1 mice.
From: Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia
A Schematic diagram illustrating the sample collection for untargeted metabolomics (n = 7). B KEGG pathway classification of metabolites identified by untargeted metabolomics. C Principal component analysis of different groups subjected to metabolomics. D Heatmap analysis depicting the top 200 metabolites identified by untargeted metabolomics. E Topology plot of KEGG pathway analysis with differential metabolites between different groups. F Volcano plot illustrating differential metabolites between different groups (VIP ≥ 1 and p-value ≤ 0.05). G Quantitative mass spectrometry validation of differential metabolites (n = 5). The bar graph data in Fig. 1 are presented as mean ± S.E.M.
